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The cover image of JGP July issue shows the mechanism by which MARP1 (orange) locks titinN2A (blue) to the thin filament in sarcomeres. Titin domains: Ig, red; PEVK, yellow; fibronectin, white. Robbert van der Pijl et al. show that MARP1 locks titin to the thin filament to increase passive force (https://bit.ly/3zLIt4J). Read JGP's July Special Issue, focused on the function and dynamic regulation of contractile systems in muscle and non-muscle cells: https://bit.ly/2TdzlFN
On the cover of JEM July issue: the antigen-presenting molecule CD1a (white) binds long chain sphingomyelin (blue), which protrudes to the CD1a surface and blocks the approach of T cell receptors (orange and pink). This original image was made by Dr. Erica Tandori, who is an artist in residence at Monash University. She has worked together with Marcin Wegrecki and Jamie Rossjohn to generate an image that captures the main message of the paper by Cotton et al. (https://bit.ly/3fvY8vG). Read JEM July Issue: https://bit.ly/3jou3BG
On JCB's July cover, this confocal image shows the accumulation of lipid droplets (BODIPY-493, green) in an astrocyte (GFAP, white) next to a neuron (3-tubulin, red) in a primary hippocampal cell-culture system. From Ralhan et al. (https://bit.ly/3d19jw6). Read JCB July issue: https://bit.ly/3y7b3vV
To coincide with #ISSCR2021, the Journal of Experimental Medicine (JEM) presents this special collection of recently published articles highlighting the latest discoveries related to #StemCell research. We hope you enjoy reading this collection, and encourage your feedback!
Swift and confidential updates to author names at any time and for any reason including changes to gender identity, marriage, divorce, religion, or other personal circumstances. We see this as a necessary step in respecting the identities of our authors. RUP Executive Director Susan King Learn more:
In this series to celebrate JEM's 125th anniversary, experts discuss significant discoveries that have revolutionized our understanding of #immunology and changed the course of modern science, highlighting some of the pivotal findings published in JEM:
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